OK, I think I nailed it down (and I may be absolutely wrong).
AD may be triggered by the brain lymphatic vessels becoming less functional (more rigid), as pointed out by *Da Mesquita et al. *. This could be compared to atherosclerosis. A. Blum has developed a method for assessing endothelial cell vitality and I wonder if a similar measure can be developed for the brain lymph system.
If true, this could explain the successful studies in AD mice using Low Intensity Focused Ultrasound. Afterall, when a sewer is blocked, we intervene mechanically to remove the blockage rather than throwing more substance at it.
Until then, keep all your vessels flexible and stay healthy!