Prevention and Early Disease Detection

What are some of the (potential) breakthroughs in prevention and early detection that could bring us closer to our vision for health in 2040?

We want to pull forward a future in which:

  • Living to 100 and over – in good health – is no longer exceptional;
  • Healthcare is holistic and biopsychosocial;
  • People are empowered to make wise health decisions;
  • Everyone has access to essential health services; and
  • Infectious diseases are effectively managed through rapid and equitable treatment distribution.

Shifting from sick-care to preventative care, and from a healthcare model that is disease-focused to one that is health-focused, is the overarching vision here.

That will obviously require changes in policy, but that’s not something XPRIZE can (directly) achieve. Rather, I would like to ask the Community to think about innovations that we could perhaps incentivize with a prize competition to help realize this future.

@GeorgePerry, @HRS, @MachineGenes, @biki, what comes to your mind?

CC @ymedan

Several exciting papers and examples of early disease detection:

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@NickOttens
A new multi-omics Tricorder that goes beyonf vital signs

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@efoehr, @Navonica, @rezafarivar, @collinsones, your expertise in diagnostics could be relevant here. What are the breakthroughs you’re looking forward to that could help with early disease detection?

@acowlagi, you may be able to tell us more about about AI and Machine Learning in particular can be applied in the next 20 years to improve prevention and early diagnosis in healthcare?

Here are several breakthrough ideas for prevention and early disease detection from our Brain Trust for your feedback:

  1. AI-powered (predictive) model that collects data from biomarkers, body scans, sensors, wearables, and user input. Contextualized to culture, place, and individual needs and wants. Integrates deep learning to predict preventable acute care. Enables users to understand their health at any time, make a plan for their health, receive actionable insights, and avoid sick-care.
  2. Digital twin of the body that tracks changes over time. Every body is unique and best compared to itself. Classic comparisons against “normative” sets are substantially less sensitive. Would catalyze new field in lifespan image analysis and diagnosis. Requires significantly cheaper MRIs.
  3. Digital twin of the planet to predict pandemics and simulate international health interventions.
  4. Model to identify hot spots for health interventions based on variety of data, including socio-economic.

@AquaDoc and @akb, I remember you commented on the Dr. AI discussion, but I think the insights you shared there are more applicable here. Would appreciate your thoughts and feedback on the 4 potential breakthroughs for prevention and early disease detection!

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This is an exciting sector. Without doubt, sensors, Big Data and AI will lead to significant radical innovations [aka moonshots / breakthroughs]. Innovation can improve every aspect of medical research and healthcare delivery. Research will be greatly accelerated leading to better diagnostics, prevention, and treatment. Health and well-being can be improved, for everyone.

There are many opportunities in the topics identified at the top of the page, and many technologies and devices will arise. In addition to the potential XPRIZE challenges for these topics there may be an additional area to consider: the development of an inter-interoperability standard between all future medical devices and information systems. However, having said this there are several standards bodies and so it would be wise to see what plans and actions they currently have in place. We need only one standard :slight_smile:

[A diverse range of incompatible systems in the US led to the need for an integrated system, which Innovation Future Specialist proposed to Novartis here: Patient Prescription Update.]

Preventative systems might include easy to use, low cost, sensors and devices. For example:

  • A skin patch that records key parameters, which are uploaded (e.g. via a smartphone for affluent users), or posted to a medical organisation for analysis
  • A device that people breath into (or spit into) daily to record key parameters - and sent electronically, or via post [perhaps requiring a very cheap data to hard-copy device - cheaper than printer + ink? Or “freeze”/protect the sample. Or simpler, just post the raw sample.]
  • Pin prick blood test.

The advantage of the electronic versions is that users are able to get real-time feedback and relevant health improvement tips (via AI in the cloud).

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Thanks for your comment @akb! Interoperability is something we’re looking into as well. Something like a “health architecture” XPRIZE that incentivizes interoperability/cross-talk between siloes, standardize data/tests, etc. We need to learn more there to understand if it’s prizable.

We could use “ease of use”, “low cost” and “provides feedback in real time” as potential criteria for a preventative health prize?

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… and privacy modes for inter-interoperability would be useful.
e.g. https://www.innovationfuturespecialist.co.uk/patientupdate/privacy.html

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This discussion has fed into our prize sketches for:

  1. Mental Health
  2. Health-Optimized Home
  3. Digital Twin

We look forward to your feedback on the prize ideas!