We are considering a competition consisting of three rounds, preceded by a brief awareness and recruitment phase.
The main elements of each round are listed below. We would appreciate your feedback on this high-level design.
Awareness and Recruitment Phase (3 months)
- Promotion of the prize
- Public feedback on competition guidelines
- Teams register
- Virtual team summit
Teams submit short proposals:
- Explaining their proposed intervention, its novelty and scalability
- Proof that they have a lab to work with
- Résumés of team members
Only the teams with the most promising proposals, as determined by a panel of independent judges, advance to Round A.
Round A: Casting Out Nets Wide (1 year)
XPRIZE provides community, training in bio-entrepreneurship, webinars, connections
Competitors draft and submit their proposal for a clinical trial:
- Preference for combination therapies that can be patented (to ensure financial incentive)
- Only supplements / nutraceuticals, OTC drugs, repurposed drugs
- Only interventions that are unlikely to require pre-clinical trials or Phase 1 clinical trials
Proposals would again be assess by a panel of independent judges (here)(https://community.xprize.org/discussion/880/judging-criteria). Teams that qualify for Round B will receive a milestone award covering their expenses to submit a proposal to the FDA or equivalent regulatory body.
Round B: Registering Trials and Early Preparations (1 year)
Partner teams with contract research organization (CRO):
- Sharing best practices and advice
- Some teams may choose to merge
- Help teams plan for clinical trials
- Connect teams with investors
- Competitors submit trial documentation to FDA or other regulatory
Teams whose trials are approved receive a second milestone award to cover their expenses during Phase 2 clinical trials.
Round C: Final Preparations and Phase 2 Clinical Trials (1.5 years)
- Scheduling interventions and events
- Obtaining compounds for interventions
- CRO recruits cohorts and manages clinical trials
- Data analysis by CRO or third party delivered to judges
Independent judges decide the winner, who are announced at an award ceremony.