First U.S. Patients Treated With CRISPR As Human Gene-Editing Trials Get Underway

First U.S. Patients Treated With CRISPR As Human Gene-Editing Trials Get Underway

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@MarthaDeevy, @abarsouk, @Elena_Milova, you may be interested in this. Any thoughts?

CRISPR offers a tempting fix to many simple and deadly genetic mutations, but we must remember the legacy of gene therapy (at the very same UPenn) some 20 years ago, when clinical trial Jesse Geisenger succumbed to rashly planned and executed new technology. There are known drawbacks to CRISPR, like the risk of off target nicking and cancer promotion, that must be addressed before large human trials

Targeted hormone replacement therapies, if initiated carefully in the appropriate clinical population, hormone replacement therapies in men and women may prevent and reverse muscle and bone loss and functional declines and perhaps promote healthy aging and longevity.