I am a huge fan of the work of XCures (https://www.xcures.com/). They are both digitizing the clinical trial process AND connecting it seamlessly to the broader healthcare system to quickly get actionable insights on treatments to oncology patients.
"The xCures platform captures Real World Evidence (RWE) from patients being treated in clinical trials, compassionate use and managed access programs, virtual and decentralized studies, investigator-initiated studies, and even N-of-1 clinical studies. The platform integrates data from all these sources, effectively creating a ‘perpetual trial’ that continuously refines treatments and improves outcomes. "
The data is then shared with a sister organization, Cancer Commons, that runs virtual tumor boards to provide any patient with a second opinion or to collaborate with their doctor.
They are also running many other projects that tackle pain points. For example, they just released a new AI system to seamlessly enroll patients in clinical trials and they run crowdsourcing sessions open to the medical community and public to help individual patients that seem to have run out of options.
All of that said, it makes me think that a potential way of framing a prize could be: Any patient in the world could instantly access the data (or knowledge gained) from any other patient’s treatment in the world.
This is a little different from the challenge of speeding up new drugs and their approval, but I am thinking it might be also very useful to create awareness about the treatments that are already out there being developed all over the world.
Or, if it is important to stick with new drug development, I guess the challenge might be: Create a new regulatory approval process that is just as safe as the current process, but 80 percent faster?