In this competition we want the competitors to demonstrate that they’ve achieved real and significant age reversal. For that, of course, we need robust, reliable and responsive aging biomarkers.
We’re currently looking at several biomarkers, including DNA methylation epigenetic clocks (GrimAge in particular), the frailty index (even though it doesn’t seem very responsive), peak exercise capacity, TNF-alpha receptor II, CRP, IL-6, GDF-15 / MIC-1, IGF-1, Cystatin C, NT-proBNP, HGBA1c, and telomere length.
Are there other biomarkers you would recommend we use? And are there ‘phenotypic’ biomarkers that you would recommend - things like improved libido, darkening / regrowing hair, smoother skin, and the likes?
Would love to hear what you think!